Director of Athletics Mark Alnutt announced the university's plans to replace Samuel effective Nov. 30, 2013.
Samuel had two years remaining on his contract.
Southeast finished the 2013 season 3-9 and tied for seventh overall in the OVC. Samuel's teams were 31-60 over an eight-year period.
The decision came three days after Southeast completed its 2013 season.
Southeast Missouri State University announced head football coach Tony Samuel will be replaced.
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